GOSTAR is the scientific database product owned by Excelra Knowledge Solutions and
is the most commonly preferred product among many users. In addition to providing
easy access to numerous databases, GOSTAR has many special features to help you to find
exactly what you're looking for.
The following are some of the features of GOSTAR that distinguish it from other scientific databases.
- GOSTAR is the library of several database information, collected from scientific experiments, all available journals, patents and published literatures
- High level defined process for manually curating the data from different sources
- Three levels of quality assurance in data mining
- Implemented standard Ontologies, wherever necessary
- NCBI and UniProtKB/Swiss-Prot classification for Proteins
- ICD10 classification for Therapeutic indication
- MedDRA classification for Adverse events
- Standardized data fields in the application (Source, Activity type, Assay method, etc.) Some of our most popular features are-
- Robust search features
- Search result customization
- Analytical tools
Robust Search Features
Search is the heart of everything that we do in GOSTAR. This combines robust capabilities with a user-friendly interface. Key features include:
Comprehensive Search Page
GOSTAR is a large application which contains huge amount of data. The system interface to users is designed in such a way that it is flexible and provides an easy access in a simple manner. Comprehensive search page allows the user to reach every corner of the backend database.
Systematic Data Fields
Organized data fields in GOSTAR helps in easy understanding and retrieving the results. You can submit your input from all possible combinations
- Structure based Search
- Activity based Search
- Bibliographic based Search
- Drug discovery life cycle phase
- Database selection feature
- Time line-based Search
Quick Search not only searches for and retrieves results it also can drill down into content and perform context-specific actions. Search inputs for quick search are Structure ID, GVK ID, Drug/Compound Name, CAS No., Protein/Target, Compound Derivative, Indications, Highest Phase, Mechanism of Action, and Reference ID.
Protein and Indication tree view provides a list of all therapeutic area / protein data available in GOSTAR based on the classification code. It gives a ready reference to the number of GVKIDs, references, and targets / therapeutic areas and sub areas, represented in different colors.
Recent Unsaved Query
Recent Unsaved Query link appears in the Search page once you have executed at least one basic search. It allows user to...
- View previously performed searches highlighted in orange tinted fields
- Re-execute any previous searches within same session
Basic search helps to cover all the details GOSTAR but when you want to specifically query on a combination of saved queries, you can use the AND /OR/NOT operator in advance search to view the desired results.
With the entry of either along with strategically placed characters, all the possible matches appear in the drop down.
A personal user profile where users can view /edit details such as User Details, Subscription Details, Transaction Details, User Management, Distribution Details, Wire Transfer Details, Status and My Downloads Details.
Search Result Customization
GOSTAR competence can be seen to its fullest extent in the search results page as it provides a lot of information in this page
Search results placed in such a way that it shows all the valid ways to refine and explore results. It exposes an array of related terms, headings, and other dimensions that equip users to find what they are looking for. The navigation prioritizes and organizes relevant information, while removing non-relevant results.
This builds context around each search, so users are constantly prompted with useful next steps. Customized views for.
- Biology (Binding, Functional/cell Assay, In vivo, ADME, Toxicity and Others.
- Chemistry (Scaffold1, Scaffold 2, Framework 2A, Framework 2B, skeleton, Ring 1 and Ring 2, Core)
Dynamic Display of Results
Based on the inputs provided in each section of the search page, results appear, the page is categorized into
- View 1 results
- View 2 results
- View 3 results
- View 4 results
Database Summary Report
GOSTAR provides individual summary of records available for the search input given. This allows users to view the records pertaining to that database only
List views have been included in the search results page so that users can quickly access the result data as per the
- Therapeutic area
- Company Name
- Assay Method
Save and Refine Query
Save query adds the query to users list in GOSTAR which is used for further reference as some users might just forget the query or they just might feel lethargic. In such cases, this action prompts them to access the query with just one click. Refine query is used to refine the search input submitted.
Search results can be exported by choosing the most convenient type,
- Multiple SAR points
- Field wise selection
- Search criteria
and export results in desired format- Excel, CSV, XML, SDF, and RDF formats.
Data Presentation Tools
To address the Screening of huge results, GOSTAR Analyzers will help in understanding the results in various dimensions like Physical property space, molecular pairs with biological activity, most common sub structures with biological activity, finding the relationship by scatter plots with Activity and Chemical properties. Sorting the molecules on the normalized activity value with a specific source, also finding the off-target activity for a compound.
Activity Analyzer - Systematic sorting of molecules based on activity value, target, source and Activity type.
Heat Map - It helps in understanding the off-target activity from the result set.
MCSS - Scaffold analysis by building a cluster tree and associated nodes with biological activity range for a given target (source and activity type dependent).
Property Space - Data appears based on the Lipinski Values, Solubility (Calculated), TPSA values. Sorting option allows user to define the value and view the results.
Scatter Plot - A scatter plot would let the user to see the relationship between different Activity properties (AP) and Physicochemical properties (PCP). Different properties included are--Molecular weight, cLogP, HB donors, HB acceptors, Log S, Log D, TPSA, Rotatable bonds, pIC50.
LE vs. LLE - This helps you to visualize the relationship between Ligand efficiency and Ligand Lipophilic efficiency.
Pairs Mapping Query - Pairs Mapping Query/Structure similarity Vs Activity or "Systematic pair wise compound comparison" helps in identifying the molecular pairs which are similar (a value of x) and different in Activity by two orders of magnitude in terms of log(Activity).
Pairs Mapping Reference - Pairs Mapping Reference/Structure similarity Vs Activity or "Systematic pair wise compound comparison" helps in identifying the molecular pairs with the given molecule which are similar (a value of x) and different in Activity by two orders of magnitude in terms of log(Activity).
Core Group - Core group analysis by building a cluster with biological activity range for a given target (source and activity type dependent).
Over View - Histograms will give the quick information from the results set on top 10 Indications, Targets, Source and Activity Types